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There are numerous ways the player can become afflicted in The Long Dark. If an affliction occurs, action must be taken or the player will die.

Affliction Cure/Solution
Food poisoning Take Antibiotics or Reishi Tea, then sleep for ten hours.
Hypothermia Stay warm for 24 consecutive hours.
Infection risk Apply Antiseptic and a Bandage, or an Old Man's Beard Wound Dressing.
Sprained ankle, Sprained wrist Take Painkillers, Rose Hip Tea, or rest for two hours.
Intestinal Parasites Take Antibiotics or Reishi Tea once per day, for 10 days.